ea0029p840 | Endocrine tumours and neoplasia | ICEECE2012
Morimoto K.
, Shibata H.
, Miyashita K.
, Kurihara I.
, Bokuda K.
, Murai-Takeda A.
, Mitsuishi Y.
, Motosugi Y.
, Jo R.
, Isobe K.
, Takekoshi K.
, Itoh H.
Introduction: Pheochromocytoma (PHEO) is a rare tumor of chromaffin cells with variable clinical presentation. Adrenal PHEOs secrete excessive amounts of noradrenaline or of noradrenaline plus adrenaline, whereas extra-adrenal PHEOs (paragangliomas) mostly secrete noradrenaline alone due to lack of expression of phenylethanolamine-N-methyltransferase (PNMT), the key enzyme converting noradrenaline into adrenaline. We report two exceptional cases of paragangliomas responsible f...